Mobility Plus formula details

Why is Mobility Plus the best choice you will make for your pet and how can each ingredient help your pet to enjoy life to the fullest, including glucosamine, chondroitin and MSM?

 

GUARANTEED ANALYSIS
each tablet contains:

Glucosamine HCL*.............................500mg
Chondroitin Sulfate*..........................200mg
MSM*.................................................125mg
Yucca Extract (4:1)*..............................75mg
DHA Omega-3 Powder..........................35mg
Ascorbic Acid (Vitamin C)…………………..25mg
Pine Bark Extract*................................15mg
(95% Proanthocyanidins)
Hyaluronic Acid*..................................10mg
Zinc*.......................................................2mg

(*Not recognized as an essential nutrient by AAFCO dog and cat nutrient profiles)

 

Glucosamine and Chondroitin:  in Mobility Plus work together to help ensure that your pet’s body is well equipped to produce adequate proteoglycans, and that there is enough space for synovial fluid to flow as needed.

Hyaluronic acid:  works to help encourage synovial fluid supply.

MSM (Methylsulfonylmethane):  is added to tackle muscle pain and inflammation. A powerful source of elemental sulfur, MSM is especially helpful when used in conjunction with glucosamine and chondroitin.

Yucca:  acts as a powerful natural anti-inflammatory agent. It contains polyphenols and saponins, is a terribly efficient antioxidant free radical scavenger and compliments our other ingredients beautifully.

Omega-3 oils (DHA):  are terrific for skin and coat, immune function, and also inflammation. This is why we add a healthy dose to each Mobility Plus tablet. DHA is also important for cognitive health, and with older animals, this is surely a good thing to preserve in any way we can!

Vitamin C:  just enough for uptake and immune system support. Important in the production of collagen which is needed for soft-tissue support for joints.

Zinc:  helps the body utilize antioxidants and is important for uptake

Pine bark extract:  is a powerful anti-inflammatory agent and source of Oligomeric Proanthocyanidin Complexes (OPC’s). Our pine bark extract contains 95% proanthocyanidins. This is important, as not all pine bark extract is the same. OPC’s act as powerful anti-inflammatory agents by inhibiting the enzyme cyclooxygenase, and is beneficial for your pet's circulation. In addition, OPC’s enhance T-helper cells (T-lymphocytes), which are essential to fighting autoimmune diseases as well as cancer.

 

 

Supporting Research on the active ingredients in Mobility Plus:

Glucosamine, Chondroitin and MSM:

American Journal of Veterinary Research 1999 Dec;60(12):1552-7: Canapp SO Jr, McLaughlin RM Jr, Hoskinson JJ, Roush JK, Butine MD:Evaluation of Glucosamine HCI and Chondroitin Sulfate as Treatment for Acute Synovitis in Dogs

Clinical Drug Investigation 2004: 24:353-363.: P.R. Usha and M.U.R Naidu: Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane (MSM) and their combination in osteoarthritis

Am J Vet Res. 1999 Dec;60(12):1552-7.Canapp SO Jr, McLaughlin RM Jr, Hoskinson JJ, Roush JK, Butine MD: Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate.

International Journal of Anti-Aging Medicine, Summer 1998, I (I);50: Ronald M. Lawrence MD,PhD: Methyl-Sulfonyl-Methane (MSM) A Double Blind of its use in Degenerative Arthritis



Oligomeric Proanthocyanidins (GSE and Pine Bark Extract)



Biotechnol Ther 1994; 5:117-26:Rong Y, Li L, Shah V, Lau BH. Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury.

Redox Report 1997; 3:219-24:Wei Z, Peng Q, Lau B. Pycnogenol enhances endothelial cell antioxidant defenses.

FEBS Lett 1998; 431:315-8: Virgili F, Kim D, Packer L. Procyanidins extracted from pine bark protect alphatocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite.


Drug Devel Industr Pharm 1998; 24:139-44Nelson A, Lau B, IDe N, Rong Y. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical induced DNA damage.

Path Biol 1990; 38:601-7: Robert A, Groult N, Six C, Robert L. Study of the effect of procyanidolic oligomers on mesenchymal cells in culture. II Attachment of elastic fibers to the cells.

Path  Biol1990;6: Robert L, Godeau G, Gavignet-Jeannin C, Groult N, Six C, Robert A. Action of procyanidolic oligomers on vascular permeability. A study by quantitative morphology.


Omega-3 Fatty Acids


Prostaglandins Leukot Essent Fatty Acids. 2005 Nov;73(5):335-41.: Hall JA, Henry LR, Jha S, Skinner MM, Jewell DE, Wander RC. Dietary (n-3) fatty acids alter plasma fatty acids and leukotriene B synthesis by stimulated neutrophils from healthy geriatric Beagles.

Journal of Nutritional Biochemistry. 2007 May 23:Hansen RA, Harris MA, Pluhar GE, Motta T, Brevard S, Ogilvie GK, Fettman MJ, Allen KG: Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease



Yucca



While there are no double blind studies on the effectiveness of Yucca, we do know that yucca is safe to give to companion animals, and that the polyphenols and saponins contained in yucca are effective antioxidants and free radical scavengers. More clinical studies are in progress and we will update this information as it becomes available.

Journal of Agricultural Food Chemistry: Oleszek W, Sitek M, Stochmal A, Piacente S, Pizza C, Cheeke P.Resveratrol and other phenolics from the bark of Yucca schidigera roezl.

Journal of Applied Nutrion 1975;27:45 51:Bingham R, Bellow BA, Bellow JG: Yucca plant saponin in the management of arthritis.

From USDA Agricultural Research Service: Botanicals Generally Recognized as Safe. http://www.ars-grin.gov/duke/syllabus/gras.htm
 
    Polyphenols:
American Journal of Clinical Nutrition: 2005 Jan;81(1 Suppl):215S-7S: Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond.
    
    Comprehensive reviews:
Journal of Inflammation (London ed). 2006 March. PR Cheeke, Piacente W Oleszek: Anti-inflammatory and anti-arthritic effects of Yucca schidigera: a review.



Hyaluronic Acid

 

note: while studies abound regarding injectable HA, we are interested in and have include studies on the affects of oral administration, since that is how we use it.

Tissue Cell 2004;36:431-438. Hegewald A, Ringe J, Bartel J, et al. Hyaluronic acid and autologous synovial fluid induce chondrogenic differentiation of equine mesenchymal stem cells: a preliminary study.

Journal of Agricultural Food Chemistry 2008, 56, 10582–10593: Balogh L, Polyak A, Mathe D, Kiraly R, Gyozo J, Schauss AG, and Bucci LR: Absorption, Uptake and Tissue Affinity of High-Molecular Weight Hyaluronan after Oral Administration in Rats and Dogs.

Seminars in Arthritis and Rheumatism: 2000 Oct; 30(2 Suppl): 19-25Dougados, M. Sodium Haluronate Therapy in Osteoarthritis: Arguments for a Potential Beneficial Structural Effect.

 


Ascorbic Acid (Vitamin C)



Gropper SS, Smith JL, Grodd JL (2004). Advanced Nutrition and Human Metabolism (4th ed.). Belmont, CA. USA: Thomson Wadsworth. pp. 260–275.

Levine M, Rumsey SC, Wang Y, Park JB, Daruwala R (2000). "Vitamin C". In Stipanuk MH. Biochemical and physiological aspects of human nutrition. Philadelphia: W.B. Saunders. pp. 541–67.

Preedy VR; Watson RR; Sherma Z (2010). Dietary Components and Immune Function (Nutrition and Health). Totowa, NJ: Humana Press.